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Tuesday, May 22, 2012

Osteoarthritis pain relief


Osteoarthritis is a degenerative joint disease that affects the knees, hips, back, and small joints in the fingers. 


Osteoarthritis affects over 20 million people in the United States, a figure that is expected to double in the next 20 years.


Avocado/soybean unsaponifiables are one of the most promising arthritis remedies. Four high-quality clinical trials suggest that avocado/soybean unsaponifiables, an extract made from avocado and soybean oils, can improve the pain and stiffness of knee and hip osteoarthritis and reduce the need for non-steroidal anti-inflammatory drugs (NSAIDs). It appears to have decrease inflammation and stimulate cartilage repair. 


In France, avocado/soybean unsaponifiables have been approved as a prescription drug. In other countries, it is available as a supplement in some health food stores or online. 


A typical dose is 300 milligrams per day. It usually takes between two weeks and two months to take effect. Studies have found no additional benefit with higher doses. 


Eating avocado and soy, even in large amounts, will not provide enough of the unsaponifiables to have a therapeutic effect. Only 1/100th of the oil is the unsaponifiable portion. 


The safety of avocado/soybean unsaponifiables has not been established in children, pregnant or nursing women.


Studies with glucosamine have found a reduction in the pain, stiffness, and swelling of arthritis. It is also thought to prevent structural damage to joints. In a study published in the Archives of Internal Medicine, participants took glucosamine or placebo for three years and were x-rayed each year to assess structural changes. Participants who took the placebo had progressive joint space narrowing, a sign of cartilage degeneration, but those who took glucosamine had no significant narrowing of joint spaces.


The dose used in studies is 1500 mg glucosamine sulfate and 800 to 1200 mg chondroitin sulfate. It's important to choose glucosamine sulfate, rather than hydrochloride, because many of the clinical studies have used the sulfate form. It usually takes 1 to 3 months to take effect. Side effects may include mild stomach discomfort, which can be alleviated by taking glucosamine with meals. Some glucosamine supplements are derived from the shells of crabs and other shellfish, so people with shellfish allergies should ensure they use synthetic glucosamine.
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